殷燕

导师介绍

导师姓名 

殷燕

导师性别 

女

职务职称 

副教授

所在院系 

化学与环境工程学院

一级学科 

化学与化工

二级学科 

制药工程

研究方向

新药研发，合成方法学研究

联系电话 

13482609592

电子邮箱 

yinyan@sit.edu.cn

个人简介

女，副教授。主讲的研究生课程有《现代制药工程实验》。已在JMC、JOC、Dyes and Pigments、Acs Med. Chem. Lett. Synthesis、BMC、BMCL、Tetrehedron、JFC、Chin. J. Chem.、Heterocycles 、synth. Commun.、J. Heterocycl. Chem.等国际著名期刊上发表SCI论文30多篇，申请专利20多项，授权4项。在美国化学会国际大会、国际氟化学大会等会议上发表论文10多篇。累计主持国家级、省部级和校级研究项目20余项。

学习与工作经历

1998年本科毕业于四川大学化学系，后分配到山东省德州学院任教，2001年考入上海有机化学研究所，2007年到美国的Emory大学进行博士后研究，同年8月转到美国Scripps研究所，2011年进入上海应用技术学院。

科研工作与成果

在研项目（2017年）

（1）“高活性的、ROCK2/1亚型选择性的ROCK2抑制剂的设计与合成研究”，2016年国家自然基金，负责人。

(2) ‘“可再生燃料电池用一体化双功能催化剂的开发”，上海市科促会2016年联盟计划，负责人。

(3)“3,3’-联二噻吩衍生物的合成及其应用研究”，2016年上海市分子催化和功能材料重点实验室研究基金，负责人 。

（4）“含氟Limk1抑制剂的设计、合成及应用研究”， 2017年中国科学院有机氟化学重点实验室开放基金,负责人。

（5） “基于“应用型”本科人才培养的《高分子材料基础》课程教学改革的探索与实践”， 2015年上海应用技术学院校级教改项目，负责人。

(6) “必博娱乐,必博娱乐官网提高学术学位研究生创新能力的探索与实践”，2016年上海应用技术学院研究生教改项目，负责人。

 (7)“阿司匹林的制备及其质量控制”，2016年校企合作实验项目，负责人。

(8)“大学生科创与制药工程专业应用型人才培养模式研究”，2016年上海应用技术大学高教课题，负责人。

代表性论文

（1） Fengkai Cheng, Yan Yin*, Guozhen Zhang,*, Yuan Wang, Wei Deng, Fanhong Wu “Optoelectronic and thermal properties of highly fluorescence emissive 2,2’-distyryl-[3,3']-bithiophenes “ Dyes and pigments 2017, 140, 222-228 (SCI, IF = 4.0).

（2） Ruihong Tao, Yan Yin*, Yongbin Duan, Yuxing Sun, Yue Sun,  Fengkai Cheng, Jinpeng Pan, Chen Lu, Yuan Wang Tetrahedron 2017，10.1016/j.tet.2017.02.030 （SCI, IF = 2.6）

(3)Zhao Zhao, Jiaxin Cui, Yan Yin,* Heng Zhang, Yecheng Liu, Rui Zeng, Chao Fang, Zhenpeng Kai, Zhonghua Wang,* Fanhong Wua* “Synthesis and biological evaluation of gem-difluoromethylenated statin derivatives as highly potent HMG-CoA reductase inhibitors Chin. J. Chem. 2016, 34, 801-808(SCI, IF = 1.9).

(4) Guofeng Sun, Fengkai Cheng, Ruiheng Tao, Yuxing Sun, Jinpeng Pang, Zhonghua, Yaohua Zhu, Zhonghua Wang, Fanhong Wu, Yan Yin* “Superacid- catalyzed Tandem Meyer-Schuster Rearrangement/Intramolecular Hydroamination of o-Aniliopropargy Alcohols to Synthesize 2, 3-Dihydro-4(1H)-quinolones” Synth. Commun. 2016, 46,1249-1256 (SCI, IF = 1.0).

(5) Yan Yin, Ke Zheng, Nibal Eid, Shannon Howard, Ji-Hak Jeong, Fei Yi, Jia Guo, Chui Min Park,  Mathieu Bibian, Weilin Wu, Pamela Hernandez, HaJeung Park, Yuntao Wu, Jun-Li Luo, Philip V. Lograsso, Yangbo Feng “Bis-aryl derivatives as potent and selective Lim kinase inhinitors” J. Med. Chem. 2015, 58, 1846-1861. (SCI, IF = 5.6)

(6) Mei Ding, Yan Yin*, Fanhong Wu, Jiaxing Cui, Hong Zhou, Guofeng Sun, Yu Jiang, Yangbo Feng* “Discovery of potent and selective urea-based ROCK inhibitors: Exploring the inhibitor’s potency and ROCK2/PKA selectivity by 3D-QSAR, molecular docking and molecular dynamics simulations” Bioorg. Med. Chem. 2015, 23, 2505-2517 (SCI, IF = 2.9).

(7) Jiaxin Cui, Mei Ding,Yan Yin*, Wei Deng, Zhonghua Wang, Yu Jiang, Hong Zhou, Guofeng Sun, Yangbo Feng “Discovery of bis-ary urea derivatives as potent and selective Limk inhibitors: Exploring Limk1 activity and Limk1/ROCK2 selectivity through computational studies” Bioorg. Med. Chem. 2015, 23, 7464-7477 (SCI, IF = 2.9)

(8) Yan Yin*, Hong Zhou, Xichen Liu, Haiying Chen, Fanhong Wu, Heng Zhang, Ruiheng Tao, Fengkai Cheng, Yangbo Feng“A Metal-Free and Recyclable Synthesis of Benzothiazoles using Thiourea as a Sulfur Surrogate”Tetrahedron Lett, 2015, 56, 1709-1712. (SCI, IF = 2.4)

(9) Yan Yin*, Hong Zhou, Guofeng Sun, Xichen Liu“m-CPBA Mediated Intramolecular Aminohydroxylation of N-Sulfonyl Aminoalkenes to Synthesize β-hydroxyl Cyclic Amines ”Journal of Heterocyclic Chemistry 2015, 1337-1345 (SCI, IF = 0.8)

(10) Yan Yin*, Guo-Feng Sun, Heng Zhang, Hong Zhou, Fan-Hong, Wu “Enatioselective Chalcogeno-Baylis-Hillman Reaction of Benzaldehydes with MVK and Acrylates Catalyzed by Chiral Thiepin-TiCl4 Complex” Chin. J. Chem. 2014, 32, 365-369. (SCI, IF = 1.9)

(11)Yan Yin; Li Lin; Claudia Ruiz; Susan Khan; Michael D Cameron; Wayne Grant; Jennifer Pocas; Nibal Eid; Hajeung Park; Thomas Schroeter; Philip V. LoGrasso; Yangbo Feng “Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors”J. Med. Chem. 2013, 56,3568-3581。（SCI, IF = 5.6）

(12) Yan Yin, Michael D. Cameron, Li Lin, Susan Khan, Thomas Schr?ter, Wayne Grant, Jennifer Pocas, Yen Ting Chen, Stephan Sch?rer, Alok Pachori, Philip LoGrasso*, Yangbo Feng* “Discovery of Highly Potent and Selective Urea-based ROCK inhibitors and their effects on the intraocular pressure in rats” ACS Med. Chem. Lett. 2010, 1, 175-179. (SCI, IF = 3.2)

(13) Yan Yin, Li Lin, Claudia Ruiz, Michael D. Cameron, Jennifer Pocas, Wayne Grant,     Thomas Schr?ter, Weimin Chen, Derek Duckett, Stephan Sch?rer, Philip LoGrasso, Yangbo Feng* “Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors” Bioorg. Med. Chem. Lett. 2009, 19, 6686-6690. (SCI, IF = 2.4)

(14) Yan Yin, Zhuo Chai, Wen-Ying Ma, Gang Zhao* “Synthesis of indoles via diethylzinc-mediated intramolecular hydroamination reaction of alkynyl sulfonamides” Synthesis 2008, 24, 4036-4040.

(15) Yan Yin, Wenying Ma, Zhuo Chai, Gang Zhao* “Et2Zn-Catalyzed Intramolecular Hydroamination of Aminoalkynes and Tandem Cyclization/Nucleophilic Addition through the Indole Zinc Salt Intermediate” J. Org. Chem. 2007, 72, 5731-5736.

(16) Yan Yin, Gang Zhao* “Heptadecafluorooctanesulfonic Acid (C8F17SO3H)      Catalyzed Intramolecular Hydroamination of Olefinic Sulfonamides in Fluorous Biphase System (FBS)” J. Fluorine Chem. 2007, 128, 40-45.

(17) Yan Yin, Gang Zhao*’”Perfluorous superacid C8F17SO3H-catalyzed intramolecular hydroamination reaction of N-protected 2-alkynylanilines: a novel synthetic method for indoles” Chimica Oggi-Chemistry Today 2007, 25, 42-45.

(18) Yan Yin, Gang Zhao* “Synthesis of Indolines and Quinoline via Cyclization of N-Arylsulfonyl-2-allylanilines Catalyzed by Br?nsted Acid” Heterocycles 2006, 68, 23-31.

社会学术团体兼职

(1) Letter in organic chemistry (SCI, IF=0.8)的常邀审稿专家； 

(2) 上海市教育评估院的评审专家。 

主要研究方向

本实验室综合运用计算机辅助药物设计、化学合成、活性测试、代谢研究等方法开发抗流感病毒、降血脂、抗心血管疾病、抗癌症的小分子药物，同时也对杂环化合物的构建方法学进行研究。